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Zynrelef is indicated in adults for instillation to produce postsurgical analgesia for up to 72 hours after soft tissue and orthopedic procedures including foot and ankle, and other procedures in which direct exposure to articular cartilage is avoided. Learn about reimbursement and pricing for zynrelef across settings of care and 340b pricing availability for eligible institutions. Zynrelef is applied without a needle into the surgical site following final irrigation and suction and prior to suturing (2.1)
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− the recommended dose of zynrelef is up to a maximum dose of 400 mg/12 mg (14 ml) (2.4). Zynrelef is a novel foundation for postoperative pain management, providing relief through 72 hours and reducing or eliminating patients’ need for opioids Zynrelef patients experienced superior pain relief through 72 hours—when pain is most severe—compared to patients receiving the current standard of care, bupivacaine hcl solution, making zynrelef the first and only product to demonstrate superiority over bupivacaine hcl solution in phase 3 studies.
When applying zynrelef during a laparoscopic procedure, zynrelef can be placed onto the fascia of the trocar and extraction sites
It should not be applied directly to the peritoneum.
